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- Positive SER-287 Phase 1b clinical and microbiome results support further development; Company plans to initiate next clinical trial in mid-2018 -
- Preliminary Phase 1b study data obtained for SER-262, the first ever rationally-designed fermented microbiome therapeutic candidate evaluated in humans–
- Collaboration with
- Conference call at
“2017 was a year of significant pipeline progress where Seres obtained
promising SER-287 Phase 1b clinical and microbiome results in Ulcerative
Colitis, advanced SER-109 into a pivotal Phase 3 study for recurrent C.
difficile infection, and entered into a strategic collaboration with
MD Anderson and the
Dr. Pomerantz continued: “Seres has an array of early and late clinical stage, as well as pre-clinical stage microbiome programs in infectious, metabolic, and immune diseases - each with compelling scientific and clinical rationale. Our near-term focus will be on the highest priority clinical programs to most effectively advance our pipeline: SER-287 for Ulcerative Colitis; SER-109 for Recurrent C. difficile infection; and the SER-401 Immuno-oncology program. We expect 2018 to be an eventful year with continued SER-109 Phase 3 study execution, and the initiation of both a next stage SER-287 Ulcerative Colitis clinical study, as well as a clinical trial evaluating adjunctive microbiome therapy in metastatic melanoma patients being treated with checkpoint inhibitors.”
SER-287 Phase 1b study clinical and microbiome results: Seres
previously reported positive results from a SER-287 Phase 1b
placebo-controlled induction study in 58 patients with
mild-to-moderate Ulcerative Colitis (UC) who were failing current
SER-287 administration resulted in a dose-dependent improvement of both clinical remission rates and endoscopic scores. Based on an intent to treat ‘missing data counted as a failure’ analysis, 40% (6 of 15) of patients in the vancomycin pre-treatment, daily SER-287 dosing arm achieved clinical remission; whereas in the placebo group 0% (0 of 11) achieved this endpoint (p-value = 0.0237).
High clinical response rates to placebo that were not statistically differentiated from the SER-287 treatment arms were also observed. Clinical response is a subjective endpoint that is prone to high variability and high placebo rates, as previously observed in several other UC trials. In the most recent
FDAregulatory guidance in August 2016, clinical remission is the only recommended primary endpoint in UC registrational studies.
The SER-287 safety and tolerability profile was favorable. Study results demonstrated no imbalance in adverse events in patients treated with SER-287, as compared to placebo. There were no drug-related serious adverse events associated with SER-287.
Analyses of study microbiome data demonstrated that SER-287 induced dose-dependent engraftment of SER-287-derived bacterial species. Differences in specific bacterial engraftment signatures were found to be associated with clinical remission. Bacterial engraftment of SER-287-derived bacterial species was durable for at least four weeks after administration of the final SER-287 dose, when final data microbiome samples were collected. In the 11 patients in this trial who achieved clinical remission (all of whom received SER-287), none had flares during the 6 months following SER-287 treatment. Finally, histologic improvement scores were demonstrated to be higher in patients treated with daily SER-287, as compared to placebo.
Seres is in discussion with the
FDAregarding the SER-287 study design and plans to initiate the next clinical study of SER-287 in UC patients in mid-2018.
SER-287 Orphan Drug Designation in Pediatric UC: The
FDAhas granted Orphan Drug Designation to Seres’ microbiome therapeutic candidate SER-287 for the treatment of UC in pediatric patients. The FDA’s designation of SER-287 follows a review of the data that established the potential uses for SER-287.
Continued execution of the SER-109 ECOSPOR III Phase 3 study: Seres
continues to progress its SER-109 Phase 3 clinical study, and plans to
enroll approximately 320 patients with multiply recurrent C.
difficile infection, at sites in both the U.S. and
Canada. Based on previously disclosed interactions with the FDA, ECOSPOR III has been designated a Phase 3 trial and the Company expects that this single pivotal study could support SER-109 registration and approval. SER-109 has been designated by the FDAas a Breakthrough Therapy and has obtained Orphan Drug Designation.
Preliminary SER-262 Phase 1b study results: Seres obtained
preliminary clinical and microbiome results from the SER-262 Phase 1b,
first-in-human, dose-escalation clinical study of SER-262 in patients
with primary C. difficile infection. SER-262 is the first
rationally-designed, fermented microbiome therapeutic candidate ever
evaluated in patients. Clinical data have been obtained from seven of
the eight planned dose escalation patient cohorts. Each cohort
included 10 patients receiving SER-262 and two patients receiving
placebo. Based on the first seven patient cohorts, SER-262 had no
drug-related serious adverse events reported. No relevant differences
were observed in the relative risk of recurrence rate in patients
administered SER-262, as compared to placebo; however, this small
cohort-based, first-in-human Phase 1b study was not powered to detect
a statistically significant difference in recurrence rates. A small
group of placebo treated patients were included in this study and, in
this group, no recurrences were observed. Of note, a low C.
difficile recurrence rate was observed in patients treated with
Vancomycin and SER-262, as compared to those treated with
Metronidazole and SER-262 (4% versus 31%, respectively). This
difference was statistically significant with a p value of 0.0049. The
medical literature suggests a recurrence rate of about 25% in patients
treated solely with Vancomycin for primary C. difficile
infection. Our data suggest that treatment with Vancomycin, followed
by SER-262, results in more robust and kinetically more rapid
engraftment, and thus may lead to corresponding clinical efficacy.
This new finding will be further evaluated to inform future
Preliminary SER-262 microbiome analysis has been conducted on the first five, lowest dose cohorts to assess drug pharmacokinetics. A majority of SER-262-derived strains were detected in patients receiving SER-262; detection of strains was variable across subjects. This is the first-time engraftment of bacteria from a fermented microbiome drug candidate has been demonstrated in the microbiome of humans. Partial engraftment of strains was also a characteristic observed in our SER-109 clinical studies, and has been reported in fecal microbiota transplant treatment of C. difficile infection. In patients where SER-262 engraftment was observed, broader microbiome changes were also observed, indicating that a limited number of engrafting species may cause global restructuring of the human microbiome. Microbiome profile differences, based on the antibiotics used to treat each patient’s C. difficile infection, were also observed. Vancomycin led to more rapid and robust engraftment of SER-262 bacterial strains, as compared to Metronidazole. More detailed microbiome and metabolomic analyses remain ongoing. These unique SER-262 proprietary human data sets will be used to inform future development of SER-262 and other fermented Seres therapeutic candidate, including but not limited to SER-301 for Inflammatory bowel disease (IBD) and SER-155 for hematopoietic stem cell transplantation (HSCT).
MD Anderson Cancer Centerand the Parker Institute for Cancer Immunotherapy: Seres, MD Anderson Cancer Center (MD Anderson), and the Parker Institute for CancerImmunotherapy ( Parker Institute), formed a collaboration to evaluate the potential of Seres’ microbiome therapeutic candidates to improve the outcomes of cancer patients treated with immuno-therapy checkpoint inhibitors. The collaborators plan to initiate a randomized, placebo-controlled study at MD Anderson, sponsored by the Parker Institutein patients with metastatic melanoma this year. The clinical trial will evaluate the impact of an anti-PD-1 checkpoint inhibitor with adjunctive microbiome therapy on patient outcomes. Seres also received an exclusive option, with pre-defined financial terms, to license intellectual property rights from MD Anderson related to the use of bacteria in combination with checkpoint inhibitors.
Seres reported a net loss of $89.4 million for the full year, as compared to a net loss of $91.6 million for the prior year. Seres reported a net loss of $29.0 million for the fourth quarter of 2017, as compared to a net loss of $25.3 million for the same period in 2016. The fourth quarter net loss was driven primarily by clinical and development expenses, personnel expenses, and ongoing development of the Company’s microbiome therapeutics platform. The fourth quarter net loss figure was inclusive of $3.1 million in recognized revenue associated with the Company’s collaboration with Nestlé Health Science.
Research and development expenses for the fourth quarter 2017 were $24.0 million, as compared to $20.3 million for the same period in 2016. The research and development expense was primarily related to Seres’ microbiome therapeutics platform, the clinical development of SER-109, SER-262 and SER-287, as well as the Company’s and immuno-oncology preclinical programs.
General and administrative expenses for the fourth quarter were $8.8 million, as compared to $8.5 million for the same period in the prior year. General and administrative expenses were primarily due to headcount, professional fees, and facility costs.
The decrease in the Company’s cash, cash equivalents and investments
balance during the quarter was $21.3 million. Seres ended the fourth
quarter with approximately
Based on the Company’s current operating plan, cash resources are expected to fund operating expenses and capital expenditure requirements, excluding net cash flows from future business development activities or potential incoming milestone payments, through the first quarter 2019.
This projection is a revision to the previous cash funding timing guidance of through 2018.
Seres is eligible to receive a substantial milestone payment, not considered in the financial guidance update, associated with the planned initiation of the next SER-287 clinical study.
Conference Call Information
Seres’ management will host a conference call today,
A webcast replay will be available on the Seres website beginning approximately two hours after the event and will be archived for approximately 21 days.
About Seres Therapeutics
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including relating to our prioritization of our assets, our development plans, the ability of ECOSPOR III to support SER-109 approval, ECORSPOR III enrollment, the promise and potential impact of any of our microbiome therapeutics or clinical trial data, our plans to initiate clinical studies of SER-287 and in I-O, the timing and results of any clinical studies, and the sufficiency of cash to fund operations.
These forward-looking statements are based on management’s current
expectations. These statements are neither promises nor guarantees, but
involve known and unknown risks, uncertainties and other important
factors that may cause our actual results, performance or achievements
to be materially different from any future results, performance or
achievements expressed or implied by the forward-looking statements,
including, but not limited to, the following: we have incurred
significant losses, are not currently profitable and may never become
profitable; our need for additional funding; our limited operating
history; our unproven approach to therapeutic intervention; the lengthy,
expensive, and uncertain process of clinical drug development, including
potential delays in regulatory approval; our reliance on third parties
and collaborators to conduct our clinical trials, manufacture our
product candidates, and develop and commercialize our product
candidates, if approved; our lack of experience in manufacturing,
selling, marketing, and distributing our product candidates; failure to
compete successfully against other drug companies; protection of our
proprietary technology and the confidentiality of our trade secrets;
potential lawsuits for, or claims of, infringement of third-party
intellectual property or challenges to the ownership of our intellectual
property; our patents being found invalid or unenforceable; risks
associated with international operations; our ability to retain key
personnel and to manage our growth; the potential volatility of our
common stock; our management and principal stockholders have the ability
to control or significantly influence our business; and we are currently
subject to securities class action litigation. These and other important
factors discussed under the caption “Risk Factors” in our Quarterly
Report on Form 10-Q filed with the
SERES THERAPEUTICS, INC.
CONSOLIDATED BALANCE SHEETS
(In thousands, except share and per share data)
|Cash and cash equivalents||$||36,088||$||54,539|
|Prepaid expenses and other current assets||5,095||5,126|
|Total current assets||155,078||198,369|
|Property and equipment, net||32,931||36,125|
|Liabilities and Stockholder's Equity|
|Accrued expenses and other current liabilities||12,513||10,812|
|Deferred revenue - related party||12,079||12,058|
|Total current liabilities||31,625||30,457|
|Lease incentive obligation, net of current portion||8,989||10,730|
|Deferred revenue, net of current portion - related party||84,847||96,756|
|Other long-term liabilities||1,129||—|
|Commitments and contingencies|
|Preferred stock, $0.001 par value; 10,000,000 shares authorized at December 31, 2017 and 2016; no shares issued and outstanding at December 31, 2017 and 2016||—||—|
|Common stock, $0.001 par value; 200,000,000 shares authorized at December 31, 2017 and 2016; 40,571,015 and 40,355,753 shares issued and outstanding at December 31, 2017 and 2016||40||40|
|Additional paid-in capital||324,376||306,931|
|Accumulated other comprehensive income (loss)||(146||)||(149||)|
|Total stockholders’ equity||60,699||132,631|
|Total liabilities, convertible preferred stock and stockholders’ equity||$||189,522||$||272,646|
SERES THERAPEUTICS, INC.
CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
(In thousands, except share and per share data)
|Year Ended December 31,|
|Collaboration revenue - related party||$||32,100||$||21,766||$||—|
|Research and development expenses||$||89,455||81,989||38,095|
|General and administrative expenses||34,040||32,616||16,761|
|Total operating expenses||123,495||114,605||54,856|
|Loss from operations||(91,395||)||(92,839||)||(54,856||)|
|Other income (expense):|
|Interest income (expense), net||1,590||1,260||83|
|Revaluation of preferred stock warrant liability||—||—||(7||)|
|Total other income (expense), net||2,015||1,260||76|
|Net loss per share attributable to common stockholders, basic and diluted||$||(2.21||)||$||(2.30||)||$||(2.33||)|
|Weighted average common shares outstanding, basic and diluted||40,449,410||39,846,928||23,532,400|
|Other comprehensive income (loss):|
|Unrealized gain (loss) on investments, net of tax of $0||3||(179||)||30|
|Total other comprehensive income (loss)||3||(179||)||30|
Carlo Tanzi, Ph.D., 617-203-3467
Vice President, Investor Relations and Corporate Communications