Entity Central Index Key
Lessee operating lease liability payments due after year four.
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Entity Current Reporting Status
Entity Current Reporting Status
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
ICFR Auditor Attestation Flag
Icfr Auditor Attestation Flag
Entity Shell Company
Entity Shell Company
Entity File Number
Entity File Number
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Entity Public Float
Entity Public Float
Entity Common Stock Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Entity Well Known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Voluntary Filers
Entity Voluntary Filers
Entity Interactive Data Current
Entity Interactive Data Current
Title of 12(b) Security
Security12b Title
Security Exchange Name
Security Exchange Name
Accrued liabilities and other liabilities current.
Contract with customer liability current related party.
Contract with customer liability noncurrent related party.
Statement Of Financial Position [Abstract]
Assets
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Short term investments
Short Term Investments
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Accounts receivable
Accounts Receivable Net Current
Total current assets
Assets Current
Property and equipment, net
Property Plant And Equipment Net
Operating lease assets
Operating Lease Right Of Use Asset
Restricted investments
Restricted Investments Noncurrent
Long term investments
Long Term Investments
Total assets
Assets
Liabilities and Stockholder's Equity (Deficit)
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued expenses and other current liabilities
Accrued Liabilities And Other Liabilities Current
Operating lease liabilities
Operating Lease Liability Current
Short term portion of note payable, net of discount
Notes Payable Current
Deferred revenue - related party
Contract With Customer Liability Current Related Party
Deferred revenue
Contract With Customer Liability Current
Total current liabilities
Liabilities Current
Long term portion of note payable, net of discount
Long Term Notes Payable
Operating lease liabilities, net of current portion
Operating Lease Liability Noncurrent
Deferred revenue, net of current portion - related party
Contract With Customer Liability Noncurrent Related Party
Deferred revenue, net of current portion
Contract With Customer Liability Noncurrent
Other long-term liabilities
Other Liabilities Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (Note 14)
Commitments And Contingencies
Stockholders’ equity (deficit):
Stockholders Equity [Abstract]
Preferred stock, $0.001 par value; 10,000,000 shares authorized at December 31, 2020 and 2019; no shares issued and outstanding at December 31, 2020 and 2019
Preferred Stock Value
Common stock, $0.001 par value; 200,000,000 shares authorized at December 31, 2020 and 2019; 91,459,239 and 70,143,252 shares issued and outstanding at December 31, 2020 and 2019
Common Stock Value
Additional paid-in capital
Additional Paid In Capital Common Stock
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income Loss Net Of Tax
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders’ equity (deficit)
Stockholders Equity
Total liabilities and stockholders’ equity (deficit)
Liabilities And Stockholders Equity
Preferred stock, par value
Preferred Stock Par Or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock Shares Authorized
Preferred stock, shares issued
Preferred Stock Shares Issued
Preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Revenue from Grant.
Revenue from research agreement.
Statement Of Income And Comprehensive Income [Abstract]
Revenue:
Revenues [Abstract]
Collaboration revenue - related party
Revenue From Contract With Customer Excluding Assessed Tax
Type of Revenue [Extensible List]
Type Of Revenue Extensible List
Grant revenue
Revenue From Grant
Collaboration revenue
Revenue From Research Agreement
Total revenue
Revenues
Operating expenses:
Operating Expenses [Abstract]
Research and development expenses
Research And Development Expense
General and administrative expenses
General And Administrative Expense
Restructuring expenses
Restructuring Charges
Total operating expenses
Operating Expenses
Loss from operations
Operating Income Loss
Other (expense) income:
Nonoperating Income Expense [Abstract]
Interest income
Investment Income Interest
Interest expense
Interest Expense Debt
Other income
Other Nonoperating Income
Total other (expense) income, net
Nonoperating Income Expense
Net loss
Net Income Loss
Net loss per share attributable to common stockholders, basic and diluted
Earnings Per Share Basic And Diluted
Weighted average common shares outstanding, basic and diluted
Weighted Average Number Of Share Outstanding Basic And Diluted
Other comprehensive (loss) income:
Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract]
Unrealized (loss) gain on investments, net of tax of $0
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
Total other comprehensive income (loss)
Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent
Comprehensive loss
Comprehensive Income Net Of Tax
Unrealized (loss) gain on investment, tax
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Tax
Stock repurchased during period share employee tax withholdings.
Stock repurchased during period value employee tax withholdings.
Stock issued during period shares at market equity offerings.
Stock issued during period value at market equity offering.
Stock issued during period to related party, shares.
Stock issued during period to related party, value.
Stock issued during period shares at market equity offering.
Statement Of Stockholders Equity [Abstract]
Statement [Table]
Statement [Table]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
Additional Paid In Capital [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Cumulative Effect, Period of Adoption
Cumulative Effect Period Of Adoption [Axis]
Cumulative Effect, Period of Adoption
Cumulative Effect Period Of Adoption [Domain]
Cumulative Effect, Period of Adoption, Adjustment [Member]
Cumulative Effect Period Of Adoption Adjustment [Member]
Statement [Line Items]
Statement [Line Items]
Beginning balance
Beginning balance, shares
Issuance of common stock from public offering, net of commissions, underwriting discounts and offering costs, value
Stock Issued During Period Value New Issues
Issuance of common stock from public offering, net of commissions, underwriting discounts and offering costs, shares
Stock Issued During Period Shares New Issues
Issuance of common stock from Securities Purchase Agreement, net of offering costs - related party, value
Stock Issued During Period To Related Party Value
Issuance of common stock from Securities Purchase Agreement, net of offering costs - related party, shares
Stock Issued During Period To Related Party Shares
Issuance of common stock from at the market equity offering, value
Stock Issued During Period Value At Market Equity Offering
Issuance of common stock from at the market equity offering, shares
Stock Issued During Period Shares At Market Equity Offering
Issuance of common stock from at the market equity offering, shares
Stock Issued During Period Shares At Market Equity Offerings
Issuance of common stock upon exercise of stock options, value
Stock Issued During Period Value Stock Options Exercised
Issuance of common stock upon exercise of stock options, shares
Stock Issued During Period Shares Stock Options Exercised
Issuance of common stock upon vesting of RSUs, net of tax withholdings, value
Restricted Stock Value Shares Issued Net Of Tax Withholdings
Issuance of common stock upon vesting of RSUs, net of tax withholdings, shares
Restricted Stock Shares Issued Net Of Shares For Tax Withholdings
Repurchase of common stock for employee tax withholdings, value
Stock Repurchased During Period Value Employee Tax Withholdings
Repurchase of common stock for employee tax withholdings, shares
Stock Repurchased During Period Share Employee Tax Withholdings
Issuance of common stock under ESPP plan, value
Stock Issued During Period Value Employee Stock Purchase Plan
Issuance of common stock under ESPP plan, shares
Stock Issued During Period Shares Employee Stock Purchase Plans
Stock-based compensation expense
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Unrealized gain (loss) on investments
Other Comprehensive Income Loss Available For Sale Securities Adjustment Before Reclassification Adjustments Net Of Tax
Net loss
Ending balance
Accounting Standards Update [Extensible List]
Accounting Standards Update Extensible List
Ending balance, shares
Non-cash operating lease cost.
Increase decrease in operating lease liabilities.
Proceeds from Securities Purchase Agreement, net of issuance costs - related party.
Proceeds from at the market equity offering net of commissions.
Proceeds from issuance of common stock and restricted common stock.
Statement Of Cash Flows [Abstract]
Cash flows from operating activities:
Net Cash Provided By Used In Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Stock-based compensation expense
Share Based Compensation
Depreciation and amortization expense
Depreciation Depletion And Amortization
Non-cash operating lease cost
Non Cash Operating Lease Cost
Amortization of debt issuance costs
Amortization Of Financing Costs
Accretion (amortization) of discount (premium) on issued debt securities
Accretion Amortization Of Discounts And Premiums Investments
Loss on disposal of property and equipment
Gain Loss On Disposition Of Assets
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Prepaid expenses and other current assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Accounts receivable
Increase Decrease In Accounts Receivable
Deferred revenue
Increase Decrease In Contract With Customer Liability
Accounts payable
Increase Decrease In Accounts Payable
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Accrued expenses and other liabilities
Increase Decrease In Accrued Liabilities And Other Operating Liabilities
Net cash (used in) operating activities
Net Cash Provided By Used In Operating Activities
Cash flows from investing activities:
Net Cash Provided By Used In Investing Activities [Abstract]
Purchases of property and equipment
Payments To Acquire Property Plant And Equipment
Purchases of investments
Payments To Acquire Investments
Sales and maturities of investments
Proceeds From Sale Maturity And Collections Of Investments
Net cash (used in) provided by investing activities
Net Cash Provided By Used In Investing Activities
Cash flows from financing activities:
Net Cash Provided By Used In Financing Activities [Abstract]
Proceeds from public offering of common stock, net of commissions, underwriting discounts and offering costs
Proceeds From Issuance Of Common Stock
Proceeds from Securities Purchase Agreement, net of issuance costs - related party
Proceeds From Securities Purchase Agreement Net Of Issuance Costs Related Party
Proceeds from issuance of note payable
Proceeds From Issuance Of Long Term Debt
Proceeds from at the market equity offering, net of commissions
Proceeds From At The Market Equity Offering Net Of Commissions
Payments of debt issuance costs
Payments Of Debt Issuance Costs
Proceeds from exercise of stock options
Proceeds From Stock Options Exercised
Proceeds from issuance of common stock and restricted common stock
Proceeds From Issuance Of Common Stock And Restricted Common Stock
Payments for repurchase of common stock for employee tax withholdings
Payments Related To Tax Withholding For Share Based Compensation
Issuance of common stock under ESPP plan
Proceeds From Stock Plans
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
Net increase (decrease) in cash, cash equivalents and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash, cash equivalents and restricted cash at beginning of year
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Cash, cash equivalents and restricted cash at end of year
Supplemental disclosure of cash flow information:
Supplemental Cash Flow Information [Abstract]
Cash paid for interest
Interest Paid Net
Supplemental disclosure of non-cash investing and financing activities:
Noncash Investing And Financing Items [Abstract]
Property and equipment purchases included in accounts payable and accrued expenses
Capital Expenditures Incurred But Not Yet Paid
Reduction of operating lease assets and operating lease liabilities from operating lease modifications or reassessments
Right Of Use Asset Obtained In Exchange For Operating Lease Liability
Documents Incorporated by Reference
Documents Incorporated By Reference [Text Block]
Accounting Policies [Abstract]
Nature of the Business and Basis of Presentation
Business Description And Basis Of Presentation [Text Block]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Fair Value Disclosures [Abstract]
Fair Value of Financial Assets and Liabilities
Fair Value Disclosures [Text Block]
Investments Debt And Equity Securities [Abstract]
Investments
Investments In Debt And Marketable Equity Securities And Certain Trading Assets Disclosure [Text Block]
Property Plant And Equipment [Abstract]
Property and Equipment, Net
Property Plant And Equipment Disclosure [Text Block]
Payables And Accruals [Abstract]
Accrued Expenses and Other Current Liabilities
Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block]
Leases [Abstract]
Leases
Lessee Operating Leases [Text Block]
Restructuring And Related Activities [Abstract]
Restructuring
Restructuring And Related Activities Disclosure [Text Block]
Debt Disclosure [Abstract]
Notes Payable
Debt Disclosure [Text Block]
Equity [Abstract]
Convertible Preferred Stock
Preferred Stock [Text Block]
Stockholders' Equity Common Stock
Shareholders Equity And Share Based Payments [Text Block]
Revenue From Contract With Customer [Abstract]
Collaboration Revenue
Revenue From Contract With Customer [Text Block]
Earnings Per Share [Abstract]
Net Loss per Share
Earnings Per Share [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Related Party Transactions [Abstract]
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Compensation And Retirement Disclosure [Abstract]
401(k) Savings Plan
Pension And Other Postretirement Benefits Disclosure [Text Block]
Use of Estimates
Use Of Estimates
Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Investments
Investment Policy [Text Block]
Restricted investments policy.
Restricted Investments
Restricted Investments Policy [Text Block]
Concentration of Credit Risk and of Significant Suppliers
Concentration Risk Credit Risk
Fair Value Measurements
Fair Value Measurement Policy Policy [Text Block]
Property and Equipment
Property Plant And Equipment Policy [Text Block]
Impairment of Long-Lived Assets
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
Research and Development Costs
Research And Development Expense Policy
Research contract costs and accruals policy.
Research Contract Costs and Accruals
Research Contract Costs And Accruals Policy [Text Block]
Patent costs policy.
Patent Costs
Patent Costs Policy [Text Block]
Accounting for Stock-Based Compensation
Share Based Compensation Option And Incentive Plans Policy
Revenue Recognition
Revenue Recognition Policy [Text Block]
Collaborative Revenue
Collaborative Arrangement Accounting Policy
Grant revenue.
Grant Revenue
Grant Revenue Policy [Text Block]
Income Taxes
Income Tax Policy [Text Block]
Segment Data
Segment Reporting Policy Policy [Text Block]
Comprehensive Loss
Comprehensive Income Policy Policy [Text Block]
Net Loss per Share
Earnings Per Share Policy [Text Block]
Leases
Lessee Leases Policy [Text Block]
Recently Adopted and Issued Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
Summary of Fair Value Hierarchy for Assets and Liabilities Measured at Fair Value on Recurring Basis
Schedule Of Fair Value Assets And Liabilities Measured On Recurring Basis Table [Text Block]
Schedule of Investments by Security Type
Debt Securities Available For Sale Table [Text Block]
Schedule of Amortized Cost and Fair Value of Investments by Contractual Maturity
Investments Classified By Contractual Maturity Date Table [Text Block]
Schedule of Property and Equipment, Net
Property Plant And Equipment [Text Block]
Schedule of accrued expense and other current liabilities.
Summary of Accrued Expenses and Other Current Liabilities
Schedule Of Accrued Expense And Other Current Liabilities Table [Text Block]
Lessee operating sublease payments to be received maturity.
Summary of Future Undiscounted Cash Inflows Under the Sublease
Lessee Operating Sublease Payments To Be Received Maturity Table [Text Block]
Schedule of operating lease assets and liabilities.
Summary of Operating Lease Assets and Liabilities
Schedule Of Operating Lease Assets And Liabilities Table [Text Block]
Summary of Lease Costs
Lease Cost Table [Text Block]
Schedule of Future Payments of Operating Lease Liabilities
Lessee Operating Lease Liability Maturity Table [Text Block]
Schedule of Components of Outstanding Restructuring Liabilities
Schedule Of Restructuring Reserve By Type Of Cost [Text Block]
Summary of Future Principal Payments Due Under Arrangement, Excluding Interest and End of Term Charge
Schedule Of Maturities Of Long Term Debt Table [Text Block]
Summary of Fair Value of Stock Option
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Summary of Stock Option Activity
Disclosure Of Share Based Compensation Arrangements By Share Based Payment Award [Text Block]
Summary of Restricted Stock Activity
Schedule Of Sharebased Compensation Restricted Stock And Restricted Stock Units Activity Table [Text Block]
Summary of Stock Based Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Changes in Contract Liabilities
Contract With Customer Asset And Liability Table [Text Block]
Basic and Diluted Net Loss per Share Attributable to Common Stockholders
Schedule Of Earnings Per Share Basic And Diluted Table [Text Block]
Summary of Potential Common Shares Excluded from Calculation of Diluted Net Loss per Share
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Schedule of Reconciliation of U.S Federal Statutory Income Tax Rate to Company's Effective Income Tax Rate
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Schedule of Net Deferred Tax Assets
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Summary of Changes In Valuation Allowance for Deferred Tax Assets
Summary Of Valuation Allowance [Text Block]
Entity incorporation month and year of incorporation.
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Nature of business and basis of presentation.
Nature of business and basis of presentation.
Nature Of Business And Basis Of Presentation [Table]
Nature Of Business And Basis Of Presentation [Table]
Product and Service
Product Or Service [Axis]
Product and Service
Products And Services [Domain]
SER-109.
SER-109 [Member]
S E R109 [Member]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Minimum [Member]
Minimum [Member]
Maximum [Member]
Maximum [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Underwritten public offering.
Underwritten Public Offering [Member]
Underwritten Public Offering [Member]
Transaction Type
Transaction Type [Axis]
Transaction
Transaction [Domain]
Securities purchase agreement.
Securities Purchase Agreement [Member]
Securities Purchase Agreement [Member]
Related Party
Related Party Transactions By Related Party [Axis]
Related Party
Related Party [Domain]
Société des Produits Nestlé.
Nestlé [Member]
Societe Des Produits Nestle [Member]
Concurrent Placement.
Concurrent Placement [Member]
Concurrent Placement [Member]
Nature Of Business And Basis Of Presentation [Line Items]
Nature Of Business And Basis Of Presentation [Line Items]
Entity incorporated month and year
Entity Incorporation Month And Year Of Incorporation
Entity incorporation, state or country code
Number of patients.
Number of patients
Number Of Patients
Option to purchase additional shares of common stock.
Common stock, share price
Share Price
Option to purchase additional shares of common stock
Option To Purchase Additional Shares Of Common Stock
Cash cash equivalents and short and long term investments.
Accumulated deficit
Cash used in operations
Cash, cash equivalents and short and long-term investments
Cash Cash Equivalents And Short And Long Term Investments
Cash equivalents original maturity maximum period.
Accounting policies.
Accounting policies.
Accounting Policies [Table]
Accounting Policies [Table]
Long-Lived Tangible Asset
Property Plant And Equipment By Type [Axis]
Long-Lived Tangible Asset
Property Plant And Equipment Type [Domain]
Laboratory equipment.
Laboratory Equipment [Member]
Laboratory Equipment [Member]
Computer Equipment [Member]
Computer Equipment [Member]
Furniture and office equipment.
Furniture and Office Equipment [Member]
Furniture And Office Equipment [Member]
Revision of Prior Period
Restatement [Axis]
Revision of Prior Period
Restatement [Domain]
Revision of Prior Period, Accounting Standards Update, Adjustment [Member]
Revision Of Prior Period Accounting Standards Update Adjustment [Member]
Accounting Standards Update
Adjustments For New Accounting Pronouncements [Axis]
Accounting Standards Update
Type Of Adoption [Member]
ASU 2014-09 [Member]
Accounting Standards Update201409 [Member]
As reported under Topic 842 [Member]
Accounting Standards Update201602 [Member]
ASU 2018-18 [Member]
Accounting Standards Update201818 [Member]
ASU 2018-13 [Member]
Accounting Standards Update201813 [Member]
Accounting Policies [Line Items]
Accounting Policies [Line Items]
Maximum maturity days for cash equivalents
Cash Equivalents Original Maturity Maximum Period
Useful life of asset
Property Plant And Equipment Useful Life
Impairment losses on long lived assets
Impairment Of Long Lived Assets Held For Use
Adoption of new revenue standard (ASC 606)
Accounts receivable
Billed Contract Receivables
Unbilled accounts receivable
Unbilled Contracts Receivable
Revenue recognized related to sales-based royalties.
Revenue recognized related to milestone payments.
Revenue related to sales-based royalties
Revenue Recognized Related To Sales Based Royalties
Revenue related to milestone payments
Revenue Recognized Related To Milestone Payments
Minimum percentage of likelihood of tax benefit being realized upon settlement.
Minimum percentage of likelihood of tax benefit being realized upon settlement
Minimum Percentage Of Likelihood Of Tax Benefit Being Realized Upon Settlement
Change in accounting principle, accounting standards update, adopted
Change In Accounting Principle Accounting Standards Update Adopted
Change in accounting principle, accounting standards update, adoption date
Change In Accounting Principle Accounting Standards Update Adoption Date
Change in accounting principle, accounting standards update, transition option elected
Change In Accounting Principle Accounting Standards Update Transition Option Elected Extensible List
Change in accounting principle, accounting standards update, immaterial effect
Change In Accounting Principle Accounting Standards Update Immaterial Effect
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Investment Type
Investment Type [Axis]
Investments
Investment Type Categorization [Member]
Commercial Paper [Member]
Commercial Paper [Member]
Corporate Bonds [Member]
Corporate Bond Securities [Member]
Certificate of Deposits [Member]
Certificates Of Deposit [Member]
Government Securities [Member]
U S Government Agencies Debt Securities [Member]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Level 1 [Member]
Fair Value Inputs Level1 [Member]
Level 2 [Member]
Fair Value Inputs Level2 [Member]
Level 3 [Member]
Fair Value Inputs Level3 [Member]
Cash and Cash Equivalents
Cash And Cash Equivalents [Axis]
Cash and Cash Equivalents
Restricted Cash And Cash Equivalents Cash And Cash Equivalents [Member]
Money Market Funds [Member]
Money Market Funds [Member]
Measurement Frequency
Fair Value By Measurement Frequency [Axis]
Measurement Frequency
Fair Value Measurement Frequency [Domain]
Fair Value, Measurements, Recurring [Member]
Fair Value Measurements Recurring [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash Equivalents:
Cash And Cash Equivalents [Abstract]
Cash equivalents
Cash And Cash Equivalents Fair Value Disclosure
Investments:
Investments Fair Value Disclosure [Abstract]
Investments
Available For Sale Securities Debt Securities
Investments
Assets Fair Value Disclosure
Fair value, assets transfers from Level 1 to Level 2 measurement
Fair Value Assets Level1 To Level2 Transfers Amount
Fair value, assets transfers from Level 2 to Level 1 measurement
Fair Value Assets Level2 To Level1 Transfers Amount
Debt Securities Available For Sale [Table]
Debt Securities Available For Sale [Table]
Schedule of Available-for-sale Securities [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost
Available For Sale Debt Securities Amortized Cost Basis
Gross Unrealized Gain
Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
Gross Unrealized Loss
Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
Fair Value
Investments [Abstract]
Restricted investment
Available-for-sale, amortized cost
Available For Sale Securities Debt Maturities Amortized Cost [Abstract]
Due in 1-year or less
Available For Sale Securities Debt Maturities Within One Year Amortized Cost
Due after 1-year through 5-years
Available For Sale Securities Debt Maturities After One Through Five Years Amortized Cost
Available-for-sale, fair value
Available For Sale Securities Debt Maturities Fair Value [Abstract]
Due in 1-year or less
Available For Sale Securities Debt Maturities Within One Year Fair Value
Due after 1-year through 5-years
Available For Sale Securities Debt Maturities After One Through Five Years Fair Value
Fair value
Investments with a contractual maturity over one year
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Construction in Progress [Member]
Construction In Progress [Member]
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Property and equipment, gross
Property Plant And Equipment Gross
Less: Accumulated depreciation and amortization
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Property and equipment, net
Accrued development and clinical manufacturing costs current.
Development and clinical manufacturing costs
Accrued Development And Clinical Manufacturing Costs Current
Payroll and payroll-related costs
Employee Related Liabilities Current
Facility and other
Other Accrued Liabilities Current
Total accrued expenses and other current liabilities
Schedule Of Operating Leased Assets [Table]
Schedule Of Operating Leased Assets [Table]
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Sublease agreement.
Sublease Agreement [Member]
Sublease Agreement [Member]
Office laboratory and manufacturing space.
Office, Laboratory and Manufacturing Space [Member]
Office Laboratory And Manufacturing Space [Member]
Operating Leased Assets [Line Items]
Operating Leased Assets [Line Items]
Lessee operating lease remaining term of contract.
Operating lease, remaining term
Lessee Operating Lease Remaining Term Of Contract
Existence of option to extend
Lessee Operating Lease Existence Of Option To Extend
Option to extend, description
Lessee Operating Lease Option To Extend
Lease extension period
Lessee Operating Lease Renewal Term
Lessee, operating sublease annual rent income year one.
Lessee, operating sublease annual rent income year Two.
Lessee, operating sublease, existence of option to extend
Lessee Operating Sublease Existence Of Option To Extend
Lessee, operating sublease, option to extend, description
Lessee Operating Sublease Option To Extend
Sublease annual rent first year
Lessee Operating Sublease Annual Rent Income Year One
Sublease annual rent second year
Lessee Operating Sublease Annual Rent Income Year Two
Lessee operating sublease payments to be received next twelve months.
Lessee operating sublease payments to be received.
2021
Lessee Operating Sublease Payments To Be Received Next Twelve Months
Future undiscounted cash inflows
Lessee Operating Sublease Payments To Be Received
Liabilities:
Liabilities [Abstract]
Total operating lease liabilities
Operating Lease Liability
Operating lease costs
Operating Lease Cost
Short-term lease costs
Short Term Lease Cost
Variable lease costs
Variable Lease Cost
Sublease income
Sublease Income
Total lease costs
Lease Cost
Rental expense related to office and laboratory space
Lease And Rental Expense
Cash payments for operating leases
Operating Lease Payments
2021
Lessee Operating Lease Liability Payments Due Next Twelve Months
2022
Lessee Operating Lease Liability Payments Due Year Two
2023
Lessee Operating Lease Liability Payments Due Year Three
2024
Lessee Operating Lease Liability Payments Due Year Four
2025 and thereafter
Lessee Operating Lease Liability Payments Due After Year Four
Total future payments of operating lease liabilities
Lessee Operating Lease Liability Payments Due
Less: imputed interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Weighted average remaining lease term
Operating Lease Weighted Average Remaining Lease Term1
Weighted average incremental borrowing rate
Operating Lease Weighted Average Discount Rate Percent
Schedule Of Restructuring And Related Costs [Table]
Schedule Of Restructuring And Related Costs [Table]
Restructuring Type
Restructuring Cost And Reserve [Axis]
Type of Restructuring
Type Of Restructuring [Domain]
Severance and other termination benefits.
Severance And Other Termination Benefits [Member]
Severance And Other Termination Benefits [Member]
Employee severance and other benefits.
Employee Severance And Other Benefits [Member]
Employee Severance And Other Benefits [Member]
Balance Sheet Location
Balance Sheet Location [Axis]
Balance Sheet Location
Balance Sheet Location [Domain]
Accrued expenses and other current liabilities.
Accrued Expenses and Other Current Liabilities [Member]
Accrued Expenses And Other Current Liabilities [Member]
Restructuring Cost And Reserve [Line Items]
Restructuring Cost And Reserve [Line Items]
Percent of reduction in headcount of employees
Restructuring And Related Cost Number Of Positions Eliminated Period Percent
Restructuring Charges
Cash payments
Payments For Restructuring
Cash payments
Liability included in accrued expenses and other current liabilities at December 31, 2019
Restructuring Reserve Current
Outstanding restructuring liabilities
Proceeds from issuance of long term debt gross.
Debt Instrument [Table]
Debt Instrument [Table]
Debt Instrument
Debt Instrument [Axis]
Debt Instrument, Name
Debt Instrument Name [Domain]
Debt instrument tranche one.
First Tranche [Member]
Debt Instrument Tranche One [Member]
Debt instrument tranche two.
Second Tranche Unavailable to Borrow Due to Not Met Milestone Requirements [Member]
Debt Instrument Tranche Two [Member]
Debt instrument tranche three.
Third Tranche Available Upon Approval on or Prior to June 30, 2021 [Member]
Debt Instrument Tranche Three [Member]
Lender Name
Line Of Credit Facility [Axis]
Line of Credit Facility, Lender
Line Of Credit Facility Lender [Domain]
Hercules Capital, Inc.
Hercules Capital, Inc. [Member]
Hercules Capital Inc [Member]
Credit Facility
Credit Facility [Axis]
Credit Facility
Credit Facility [Domain]
Loan and security agreement.
Loan and Security Agreement [Member]
Loan And Security Agreement [Member]
Long-term Debt, Type
Longterm Debt Type [Axis]
Long-term Debt, Type
Longterm Debt Type [Domain]
Term loan facility.
Term Loan Facility [Member]
Term Loan Facility [Member]
Variable Rate
Variable Rate [Axis]
Variable Rate
Variable Rate [Domain]
Prime Rate [Member]
Prime Rate [Member]
Current liability.
Current Liability [Member]
Current Liability [Member]
Non-current liability.
Non-current Liability [Member]
Non Current Liability [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Credit facility, aggregate principal amount
Line Of Credit Facility Maximum Borrowing Capacity
Gross proceeds from debt
Proceeds From Issuance Of Long Term Debt Gross
Debt instrument, variable rate
Debt Instrument Basis Spread On Variable Rate1
Credit facility, interest rate
Line Of Credit Facility Interest Rate During Period
Credit facility, payment terms
Line Of Credit Facility Frequency Of Payment And Payment Terms
Percentage of prepayment amount during first year following closing date.
Percentage of prepayment amount during second year following closing date.
Percentage of prepayment amount during third year following closing date.
Percentage of prepayment amount during first year
Percentage Of Prepayment Amount During First Year Following Closing Date
Percentage of prepayment amount during second year
Percentage Of Prepayment Amount During Second Year Following Closing Date
Percentage of prepayment amount during third year
Percentage Of Prepayment Amount During Third Year Following Closing Date
Debt instruments prepayment percentage.
Debt Instrument prepayment charges.
Debt instrument additional advance prepayments percentage.
Prepayment or repayment percentage
Debt Instruments Prepayment Percentage
Prepayment or repayment charge
Debt Instrument Prepayment Charges
Additional advance prepayment or repayment percentage
Debt Instrument Additional Advance Prepayments Percentage
Carrying value of debt
Debt Instrument Carrying Amount
Debt instrument, interest rate effective percentage
Debt Instrument Interest Rate Effective Percentage
2021
Long Term Debt Maturities Repayments Of Principal In Next Twelve Months
2022
Long Term Debt Maturities Repayments Of Principal In Year Two
2023
Long Term Debt Maturities Repayments Of Principal In Year Three
Total
Long Term Debt
Interest expense
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Initial Public Offering ("IPO") [Member]
I P O [Member]
At the market equity offering program.
At The Market Equity Offering Program [Member]
At The Market Equity Offering Program [Member]
Two thousand nineteen sales agreement.
2019 Sales Agreement [Member]
Two Thousand Nineteen Sales Agreement [Member]
Two thousand nineteen and two thousand twenty sales agreement.
2019 and 2020 Sales Agreement [Member]
Two Thousand Nineteen And Two Thousand Twenty Sales Agreement [Member]
Cowen and company limited liability company.
Cowen And Company, LLC [Member]
Cowen And Company Limited Liability Company [Member]
Underwriting Agreement.
Underwriting Agreement [Member]
Underwriting Agreement [Member]
Cowen and Company, LLC and Piper Sandler & Co.
Cowen and Company, LLC and Piper Sandler & Co. [Member]
Cowen And Company L L C And Piper Sandler Co [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock, shares issued
Net proceeds from sale of common stock
Percentage of commission on sale of common stock.
Gross proceeds from issuance of common stock.
Gross proceeds from sale of common stock
Gross Proceeds From Issuance Of Common Stock
Percentage of commission on sale of common stock
Percentage Of Commission On Sale Of Common Stock
Option exercisable period for purchase additional shares.
Option exercisable period for purchase additional shares
Option Exercisable Period For Purchase Additional Shares
Share-based compensation arrangement by share based payment award stock options term.
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Two thousand twelve stock incentive plan.
2012 Stock Incentive Plan [Member]
Two Thousand Twelve Stock Incentive Plan [Member]
Exercise price per share of common stock expressed as a percentage
Sharebased Compensation Arrangement By Sharebased Payment Award Purchase Price Of Common Stock Percent
Stock option term
Sharebased Compensation Arrangement By Share Based Payment Award Stock Options Term
Stock incentive plan description
Share Based Compensation Arrangement By Share Based Payment Award Description
Stock option granted vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Stock option expiration period
Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period
Shares available for future grant
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Percentage common stock outstanding shares.
Twenty fifteen incentive plan.
2015 Incentive Award Plan [Member]
Twenty Fifteen Incentive Plan [Member]
Number of shares initially reserved for issuance
Common Stock Capital Shares Reserved For Future Issuance
Percentage of common stock shares outstanding
Percentage Common Stock Outstanding Shares
2015 Employee Stock Purchase Plan.
2015 Employee Stock Purchase Plan [Member]
Two Thousand Fifteen Employee Stock Purchase Plan [Member]
Aggregate shares of common stock reserved for issuance
Deferred Compensation Arrangement With Individual Common Stock Reserved For Future Issuance
Shares issued under ESPP
Offering period under the plan.
Percentage of purchase price with respect to each offering period.
Percentage of eligible earning contributed toward semi-annual purchase of common stock
Defined Contribution Plan Maximum Annual Contributions Per Employee Percent
Offering period under the plan
Offering Period Under The Plan
Percentage of purchase price with respect to each offering period
Percentage Of Purchase Price With Respect To Each Offering Period
Risk-free interest rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Expected term (in years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Expected volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate
Expected dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Stock-based compensation expense
Allocated Share Based Compensation Expense
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Stock Option Valuation [Member]
Employee Stock Option [Member]
Number of Shares, Beginning Balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Number of Shares, Granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Number of Shares, Exercised
Number of Shares, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Number of Shares, Ending Balance
Number of Shares, Options exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Weighted Average Exercise Price, Beginning Balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Weighted Average Exercise Price, Granted
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Weighted Average Exercise Price, Exercised
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Weighted Average Exercise Price, Forfeited
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Weighted Average Exercise Price, Ending Balance
Weighted Average Exercise Price, Options exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Weighted Average Remaining Contractual Term, Outstanding
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Weighted Average Remaining Contractual Term, Options exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Aggregate Intrinsic Value, Outstanding
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Aggregate Intrinsic Value, Options exercisable
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Performance Shares [Member]
Performance Shares [Member]
Weighted average grant-date fair value of stock options
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Intrinsic Value, Stock options exercised
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Performance-based stock options to granted
Stock options exercisable
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Number
Stock based compensation expense for stock options
Restricted Stock Units [Member]
Restricted Stock Units R S U [Member]
Number of Shares, Unvested restricted stock units, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Number of Shares, Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Number of Shares, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period
Number of Shares, Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Number of Shares, Unvested restricted stock units, Ending balance
Weighted Average Grant Date Fair Value, Unvested restricted stock units, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Unvested restricted stock units, Ending balance
Aggregate intrinsic value, vested
Sharebased Compensation Arrangement By Sharebased Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value Vested
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and development expenses [Member]
Research And Development Expense [Member]
General and administrative expenses [Member]
General And Administrative Expense [Member]
Stock options and restricted stock units.
Stock Options and Restricted Stock Units [Member]
Stock Options And Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense
Unrecognized stock- based compensation cost
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Share Based Awards Other Than Options
Weighted average period over which unrecognized compensation cost is expected to be recognized
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Maximum development milestone payments to be received.
Maximum regulatory payments to be received.
Maximum amount to be received on achievement of certain commercial milestones.
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Nestle health science.
Nestlé Health Science [Member]
Nestle Health Science [Member]
Phase two study.
Phase 2 [Member]
Phase Two Study [Member]
Phase three study.
Phase 3 [Member]
Phase Three Study [Member]
Phase 2b Study.
Phase 2b [Member]
Phase Two B Study [Member]
Phase 1b Study.
Phase 1b [Member]
Phase One B Study [Member]
Research collaboration and option agreement.
Research Agreement [Member]
Research Collaboration And Option Agreement [Member]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
AstraZeneca, Incorporated.
AstraZeneca Inc. [Member]
Astra Zeneca Incorporated [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront cash payment
Contract With Customer Liability
Maximum development milestone payments to be received
Maximum Development Milestone Payments To Be Received
Maximum regulatory payments to be received
Maximum Regulatory Payments To Be Received
Maximum amount to be received on achievement of certain commercial milestones
Maximum Amount To Be Received On Achievement Of Certain Commercial Milestones
Collaborative arrangement upfront milestone payment receivable.
Upfront collaboration milestone payments receivable
Collaborative Arrangement Upfront Milestone Payment Receivable
Proceeds on achievement of development milestone
Proceeds From Collaborators
Collaborative arrangement upfront license fee received.
Upfront collaboration/license fee
Collaborative Arrangement Upfront License Fee Received
Transaction price allocated to remaining performance obligations
Revenue Remaining Performance Obligation
Transaction price of milestone payment to be received.
Transaction price of milestone payment to be received
Transaction Price Of Milestone Payment To Be Received
Revenue information used to determine transaction price
Revenue Information Used To Determine Transaction Price
Contract modification catch-up adjustment
Contract With Customer Liability Cumulative Catch Up Adjustment To Revenue Modification Of Contract
Cumulative catch-up revenue
Contract With Customer Asset Cumulative Catch Up Adjustment To Revenue Change In Measure Of Progress
Deferred revenue from related party.
Deferred revenue
Deferred Revenue From Related Party
Minimum exclusivity period.
Number Of installments.
Minimum exclusivity period
Minimum Exclusivity Period
Number of installments
Number Of Installments
Option exercise period from exclusivity period.
Terms of the definitive license agreement good faith negotiation period.
Other terms of definitive license agreement period.
Option exercise period from exclusivity period
Option Exercise Period From Exclusivity Period
Terms of the definitive license agreement good faith negotiation period
Terms Of Definitive License Agreement Good Faith Negotiation Period
Other terms of definitive license agreement period
Other Terms Of Definitive License Agreement Period
Research agreement effective termination date.
Notice period for termination of agreement.
Termination date
Research Agreement Effective Termination Date
Termination notice period
Notice Period For Termination Of Agreement
Research and development fixed consideration.
Research and development estimated reimbursement costs.
Research and development fixed consideration
Research And Development Fixed Consideration
Research and development estimated reimbursement costs
Research And Development Estimated Reimbursement Costs
Research and development reimbursement costs incurred.
Reimbursement of research and development costs incurred
Research And Development Reimbursement Costs Incurred
Contract with customer liability with related party additions.
Contract with customer liability revenue recognized with related party.
Contract with customer liability with related party.
Deferred revenue - related party, Balance at beginning of period
Contract With Customer Liability With Related Party
Deferred revenue - related party, Additions
Contract With Customer Liability With Related Party Additions
Deferred revenue - related party, Deductions
Contract With Customer Liability Revenue Recognized With Related Party
Deferred revenue - related party, Balance at end of period
Contract with customer liability additions.
Deferred revenue, Balance at beginning of period
Deferred revenue, Additions
Contract With Customer Liability Additions
Deferred revenue, Deductions
Contract With Customer Liability Revenue Recognized
Deferred revenue, Balance at end of period
Revenue recognized in the period from:
Revenue Recognition [Abstract]
Amounts included in the contract liability at the beginning of the period
Net Income Loss Available To Common Stockholders Basic [Abstract]
Numerator:
Net Income Loss [Abstract]
Net loss attributable to common stockholders
Net Income Loss Available To Common Stockholders Basic
Denominator:
Weighted Average Number Of Shares Outstanding [Abstract]
Earnings Per Share Diluted [Abstract]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Stock Options to Purchase Common Stock [Member]
Unvested restricted stock units.
Unvested Restricted Stock Units [Member]
Unvested Restricted Stock Units [Member]
Employee stock purchase plan.
Shares Issuable under Employee Stock Purchase Plan [Member]
Employee Stock Purchase Plan [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potential common shares excluded from calculation of diluted net loss per share
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Other Commitments [Table]
Other Commitments [Table]
Loss Contingency Nature
Loss Contingencies By Nature Of Contingency [Axis]
Loss Contingency, Nature
Loss Contingency Nature [Domain]
Indemnification Agreement [Member]
Indemnification Guarantee [Member]
Legal contingencies.
Legal Contingencies [Member]
Legal Contingencies [Member]
Other Commitments [Line Items]
Other Commitments [Line Items]
Obligations accrued
Contractual Obligation
Income tax disclosure.
Income tax disclosure.
Income Tax Disclosure [Table]
Income Tax Disclosure [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Federal [Member]
Domestic Country [Member]
State [Member]
State And Local Jurisdiction [Member]
Tax Credit Carryforward
Tax Credit Carryforward [Axis]
Tax Credit Carryforward, Name
Tax Credit Carryforward Name [Domain]
Research and Development Tax Credit [Member]
Research [Member]
Orphan drug credit carryforward.
Orphan Drug Credit Carryforwards [Member]
Orphan Drug Credit Carryforward [Member]
Tax Period
Tax Period [Axis]
Tax Period
Tax Period [Domain]
Before two thousand eighteen.
Before 2018 [Member]
Before Two Thousand Eighteen [Member]
After two thousand seventeen.
After 2017 [Member]
After Two Thousand Seventeen [Member]
After two thousand seventeen and before January one, two thousand twenty one.
After 2017 and Before January 1, 2021 [Member]
After Two Thousand Seventeen And Before January One Two Thousand Twenty One [Member]
After January one, two thousand twenty one.
After January 1, 2021 [Member]
After January One Two Thousand Twenty One [Member]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
Massachusetts [Member]
MASSACHUSETTS
Income Tax Disclosure [Line Items]
Income Tax Disclosure [Line Items]
Income tax benefit
Income Tax Expense Benefit
Federal statutory income tax rate
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
Research and development tax credits
Effective Income Tax Rate Reconciliation Tax Credits Research
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation State And Local Income Taxes
Stock-based compensation
Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost
Other
Effective Income Tax Rate Reconciliation Other Reconciling Items Percent
Change in deferred tax asset valuation allowance
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Effective income tax rate
Effective Income Tax Rate Continuing Operations
Deferred tax assets capitalized organization costs.
Deferred tax assets lease liability.
Deferred tax assets deferred expense capitalized research and development costs.
Deferred tax assets section 163(j) limitation CARES act.
Deferred tax liabilities, right of use assets.
Deferred tax assets:
Deferred Tax Assets Net [Abstract]
Net operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards
Research and development tax credit carryforwards
Deferred Tax Assets Tax Credit Carryforwards Research
Capitalized organization costs
Deferred Tax Assets Capitalized Organization Costs
Stock-based compensation expense
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Lease Liability
Deferred Tax Assets Lease Liability
Charitable Contributions
Deferred Tax Assets Charitable Contribution Carryforwards
Deferred Revenue
Deferred Tax Assets Deferred Income
Accrued expenses
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Accrued Liabilities
Capitalized research and development expenses
Deferred Tax Assets Deferred Expense Capitalized Research And Development Costs
Section 163(j) limitation
Deferred Tax Assets Section163 J Limitation C A R E S Act
Total deferred tax assets
Deferred Tax Assets Gross
Deferred tax liabilities:
Deferred Tax Liabilities Net [Abstract]
Depreciation and amortization
Deferred Tax Liabilities Property Plant And Equipment
Right of use assets
Deferred Tax Liabilities Right Of Use Assets
Total deferred tax liabilities
Deferred Income Tax Liabilities
Valuation allowance
Deferred Tax Assets Valuation Allowance
Net deferred tax assets
Deferred Tax Assets Liabilities Net
Tax credit carryforward expiration year.
Operating loss carryforwards expiration year.
Net operating losses on taxable income threshold percentage.
Net operating loss carryforwards
Operating Loss Carryforwards
Net operating loss carry forwards, expiration year, start
Operating Loss Carryforwards Expiration Year
Taxable income on NOL
Net Operating Losses On Taxable Income Threshold Percentage
Tax credit carryforwards
Tax Credit Carryforward Amount
Tax credit carryforwards, expiration year, start
Tax Credit Carryforward Expiration Year
Decrease in valuation allowance deferred tax asset amount.
Increase in valuation allowance deferred tax asset.
Valuation Allowance [Abstract]
Valuation allowance at beginning of year
Decreases recorded as benefit to income tax provision
Decrease In Valuation Allowance Deferred Tax Asset Amount
Increases recorded to income tax provision
Increase In Valuation Allowance Deferred Tax Asset
Valuation allowance as of end of year
Unrecognized tax benefits
Unrecognized Tax Benefits
Schedule Of Related Party Transactions By Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Flagship Pioneering.
Flagship Pioneering [Member]
Flagship Pioneering [Member]
Related Party Transaction
Related Party Transaction [Axis]
Related Party Transaction
Related Party Transaction [Domain]
Other Income [Member]
Other Income [Member]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Collaboration revenue - related party
Deferred revenue
Payments under agreements with related party
Related Party Transaction Selling General And Administrative Expenses From Transactions With Related Party
Due from related party for the reimbursement of development costs
Due From Related Parties Current
Sub lease commencement date.
Sub lease commencement date
Sub Lease Commencement Date
Sublease income
Cash received from related party transaction
Related Party Transaction Other Revenues From Transactions With Related Party
Employer match of employee contributions
Defined Contribution Plan Employer Matching Contribution Percent Of Match
Employee deferral subject to employer match
Defined Contribution Plan Employer Matching Contribution Percent
Employer contribution expenses
Defined Contribution Plan Cost Recognized